Principal Scientist / Principal Scientist II – Associate Director, Translational Biology

Written By Jamison Wright

Join a fast-paced, collaborative, cutting-edge start-up biotechnology company developing the next generation of therapeutic bispecific antibodies focused on extracellular protein degradation. Our mission is to generate novel transformative medicines for the patients that need it most. We are seeking a motivated, talented, and collaborative scientist with a strong background in translational research, including cancer biology, in vivo and in vitro pharmacology, nonclinical/IND-enabling studies, and antibody drug discovery. The candidate will work with cross-functional teams to drive the progression of our pipeline programs from discovery research through development candidate nomination and IND submission.

The candidate will be responsible for a variety of translational oncology and pharmacology activities, supporting the design, coordination, execution, and analysis of translational oncology models, in addition to primary cell and tissue-based translational assays. The candidate will also support nonclinical pharmacology and toxicology IND-enabling studies.

The successful candidate will have demonstrated a sustained track record of being an impactful scientist, who is comfortable in a fast-paced early R&D start-up environment.

Day-to-day responsibilities may include:

  • Lead the selection, design, coordination, execution, and analysis of mouse and other translational oncology models in partnership with EpiBio teams and external CROs.  The role will incorporate efficacy, pharmacodynamics, mechanism of action, pharmacokinetic and toxicology studies, as well as presenting results in internal project team meetings.

  • Additional responsibilities include establishing the clinical path for new drug candidates including investigating target expression in primary tissues and cells (e.g. histopathology, flow cytometry or other protein detection methods) and executing primary cell/tissue-based assays related to drug candidate mechanism of action, toxicity and/or immune function (e.g. ADCC/ADCP). 

  • The role will also support nonclinical pharmacology and toxicology studies through IND-enablement.

Required Education / Experience and Skills:

  • PhD degree in cell biology, cancer biology, immunology, or related discipline with experience in biologics/oncology therapeutics discovery and/or translational research (industry experience required)

  • Expertise with oncology-related in vivo pharmacology models and downstream tissue analysis for mechanism of action investigation (cell-line and patient-derived tumor models, pharmacodynamic biomarkers, pharmacokinetics, etc.)

  • Expertise with protein-based target expression/prevalence studies in primary human tissues (IHC, IF, flow cytometry, etc.)

  • Experience in primary immune cell, cancer cell-based or reporter cell-based assay development (primary immune cell enrichment, cytokine readouts such as Luminex/MSD, Incuycte, flow cytometry, ELISA, western blot, WES, qPCR, transfection, etc.)

  • Experience with public oncology/human tissue database mining (e.g. TCGA, GTEX, Blueprint, DepMAP, etc.)

  • Experience with the IND process including the nonclinical pharmacology and toxicology sections

  • Strong written and oral communication skills as demonstrated with a record of publications in high-quality scientific journals, patents and/or conference presentations

  • Ability to manage multiple projects simultaneously

  • Foundational computer skills, including Microsoft Office Suite and the Internet. Ability to navigate at a basic level within web-based applications.

  • Working knowledge of online teleconferencing software (e.g, Zoom or Teams).

  • Advanced skills with Microsoft applications which may include Outlook, Word, Excel, PowerPoint, Access and/or other web-based applications. May produce complex documents, perform analysis, and maintain databases.

Job level will be based on prior experience and accomplishment. The expected base salary range for this role is $171,000 - $209,000.

The above pay range is what we reasonably expect to pay for this position.  Individual compensation is based on various factors, including experience, education, skillset, and geographic location.  This pay range is for the Bay Area, CA, location and may be adjusted to the labor market in other geographic areas. 

Benefits & Perks: 

  • Comprehensive and competitive medical, dental, vision, Company Funded HSA

  • Company-paid short and long-term disability, and life insurance

  • Voluntary life insurance plans are available for employees and dependent (s)

  • Competitive base pay, bonus, and equity package 

  • Flexible Vacation program for Exempt Employees plus 12 paid Holidays & Winter Break

  • 10 weeks Parental Bonding Leave

  • Epi 401(k) Plan 

EpiBiologics is an Equal Opportunity Employer:

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. If you think you will excel in this role, but perhaps don’t tick every box, we encourage you to apply!

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation. 

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Jamison Wright https://jamisonwright.com